The 2003 Chicagoe Cubs pitching staff had 1,404 strikeouts for the Major League record.
260
Matt Kilroy holds the record for most strikeouts by a pitcher in a single season with 513 in 1886. Nolan Ryan holds the modern day record with 383 in 1973.
Johan Santana with 265 strikeouts in 2004.
Sandy Koufax with 382 strikeouts in 1965.
Cecil Fielder with 182 strikeouts for the 1990 Tigers.
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Mickey Lolich in 1971.
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372 for the Arizona Diamondbacks in 2001.
As of the 2010 season, the Yankees team record for strikeouts by a pitcher in a season is 248 by Ron Guidry in 1978.
Justin Verlander 90 strikeouts right now
Randy Johnson: Entering the 2008 season, he was 56 strikeouts behind Roger Clemens for second all time. Through his August 6th start against Pittsburgh, he had 114 strikeouts for the season, closing the gap to Nolan Ryan (1st all-time) to slightly under 1,000 strikeouts. http://www.enth.com/Home.aspx?q=what+pitcher+has+the+most+strikeouts