Sandy Koufax with 382 strikeouts in 1965.
As of the 2008 season, that is Ferguson Jenkins who struck out 274 batters in 1970.
Matt Kilroy holds the record for most strikeouts by a pitcher in a single season with 513 in 1886. Nolan Ryan holds the modern day record with 383 in 1973.
As of the 2010 season, the Yankees team record for strikeouts by a pitcher in a season is 248 by Ron Guidry in 1978.
Adam Dunn
Matt Kilroy of the Baltimore Orioles had 513 strikeouts in 1886. Nolan Ryan who had 383 strikeouts in 1973 for the California Angels holds the modern day record. The record for most strikeouts in a single game is 20, shared by Kerry Wood and Roger Clemens, who did it twice. -------------------------------------------------------------------------------------------------------------------------- Not really germaine to the question but the record for most strikeouts in a game is 21 held by Tom Cheney of the Washington Senators who did the deed in 1962 against the Baltimore Orioles in a 16 inning game. Wood, Clemens, and Randy Johnson hold the record for strikeouts in a 9 inning game with 20.
Tom Cheney of the Washington Senators holds the MLB record for most strikeouts in a single game when he struckout 21 Baltimore Orioles batters in a 16 inning game in 1962. Kerry Wood, Randy Johnson, and Roger Clemens (twice) hold the MLB record for most strikeouts in a 9 inning game with 20. == ==
For the Los Angeles Angels single game records, the pitcher with the most strikeouts in one game of nine innings is Nolan Ryan with 19. The pitcher with the most strikeouts in a game with extra innings is also Nolan Ryan with 19. The pitcher with the most strikeouts in one inning is Chuck Finley with 4. The record for most strikeouts in a game by the team is 18. The player with the most strikeouts in one game while batting is Dallas McPherson with 4. The most strikeouts by a batter in a game with extra innings is Billy Cowan with 6.
Bob Gibson holds the World Series record for most strikeouts by a pitcher in a World Series (35 in 1968) and most strikeouts by a pitcher in a single game (17 in Game 1 of the 1968 WS). He is tied for most games won by a pitcher in a World Series (3 in 1967).
Johnny Mize of the New York Giants had 51 home runs and 42 strikeouts in the 1947 season.
Buddy Scholtz had 26 strikeouts in a game for Miami University.
Through the 2013 season, Mark Reynolds, who at the time played for the Arizona Diamondbacks, holds the MLB record for striking out in a season with 223 strikeouts in 2009.In 2010, Reynolds became the fastest player to reach 100 strikeouts in a season, doing this in only 67 games, and was on pace to break his own record. He finished the 2010 season with 211 strikeouts, which is fourth all-time.
Ron Guidry had 248 strikeouts in the 1978 season. This broke the single season record set by New York Yankee Jack Chesbro who had 439 in 1906.