Matt Kilroy holds the record for most strikeouts by a pitcher in a single season with 513 in 1886. Nolan Ryan holds the modern day record with 383 in 1973.
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actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
As of the 2010 season, the Yankees team record for strikeouts by a pitcher in a season is 248 by Ron Guidry in 1978.
Nolan Ryan with 5714. he had 300 strikeouts 6 times and almost 400 strikeouts. Nolan Ryan played a 28 year career.He led the American league in strikeouts 10 times.He has a record pitching a no hitter at 43 and 44 with 7 no hitters that's a record.
Through games played on September 13, 2011 that is Adam Dunn with 195 strikeouts in 2004. Drew Stubbs of the 2011 Reds has 190 strikeouts so far and will probably set a new Reds record and surpass 200.
Johan Santana with 265 strikeouts in 2004.