The most strikeouts in baseball history in one inning is four. This has happened just 72 times in baseball history.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
Johan Santana with 265 strikeouts in 2004.
In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
Sandy Koufax with 382 strikeouts in 1965.
Randy Johnson: Entering the 2008 season, he was 56 strikeouts behind Roger Clemens for second all time. Through his August 6th start against Pittsburgh, he had 114 strikeouts for the season, closing the gap to Nolan Ryan (1st all-time) to slightly under 1,000 strikeouts. http://www.enth.com/Home.aspx?q=what+pitcher+has+the+most+strikeouts
15.
Nolan Ryan
At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.
Randy Johnson
Nolan Ryan holds the career record with 5,714 strikeouts.
For the Los Angeles Angels single game records, the pitcher with the most strikeouts in one game of nine innings is Nolan Ryan with 19. The pitcher with the most strikeouts in a game with extra innings is also Nolan Ryan with 19. The pitcher with the most strikeouts in one inning is Chuck Finley with 4. The record for most strikeouts in a game by the team is 18. The player with the most strikeouts in one game while batting is Dallas McPherson with 4. The most strikeouts by a batter in a game with extra innings is Billy Cowan with 6.