Nolan Ryan holds the record for most career strikeouts with 5.714.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
Nolan Ryan with 5,714 career strikeouts.
Nolan Ryan holds the career record with 5,714 strikeouts.
Pitcher Whitey Ford has the most career strikeouts in the World Series with 94.
Ryan Howard holds the record for most strikeouts for a batter in a World Series with 13 in 2009. Bob Gibson holds the record for most strikeouts for a pitcher with 35 in 1968.