In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
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In MLB, that was J.R. Richard of the Houston Astros with 15 strikeouts in a 5-3 complete game victory over the San Francisco Giants on September 5, 1971.
The most strikeouts by a single pitcher in a single MLB game is 21 by Tom Cheney of the Washington Senators in a game against the Baltimore Orioles in 1962. The game lasted 16 innings and Cheney pitched all 16. The most strikeouts by a single pitcher in a 9 inning game is 20 and is held jointly by Kerry Wood, Randy Johnson, and Roger Clemens.
actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
Nolan Ryan holds 5,714 strikeouts for his career and to this point no one else in the majors have struck out more than 5000 batters.
Roger Clemens