Nolan Ryan with 5714
Nolan Ryan has the most career strikeouts with 5,714.
In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
78..
Johan Santana with 265 strikeouts in 2004.
If you are talking about pitchers and who has the most K's, the answer is Nolan Ryan with 5,714 strikeouts. If you are talking about batters who have struck out at the plate, the leader is Reggie Jackson with 2,597 strikeouts.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.
Sandy Koufax with 382 strikeouts in 1965.
Whitey Ford has the most career World Strikeouts with 94.
Mark Reynolds holds the record for most strikeouts in a single season with 223 strikeouts in 2009.
actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
Reggie jackson