Nolan Ryan has the most career strikeouts with 5,714.
Nolan Ryan holds the career record with 5,714 strikeouts.
Tom Cheney of the Washington Senators holds the MLB record for most strikeouts in a single game when he struckout 21 Baltimore Orioles batters in a 16 inning game in 1962. Kerry Wood, Randy Johnson, and Roger Clemens (twice) hold the MLB record for most strikeouts in a 9 inning game with 20. == ==
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
1,596 career strikeouts
actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
Nolan Ryan holds 5,714 strikeouts for his career and to this point no one else in the majors have struck out more than 5000 batters.
No Brewers pitcher has 1118 career strikeouts
Mickey Mantle is second on the all-time Yankees list for most strikeouts, with 1,710. Derek Jeter is first.
Through September 21, Clemens has 4672 career strikeouts
4869 strikeouts
Barry Bonds has 1,539 career strikeouts.
As of September, 2008: Pitching: Mickey Lolich - 2,679 Batting: Lou Whitaker - 1,099