If you are talking about pitchers and who has the most K's, the answer is Nolan Ryan with 5,714 strikeouts. If you are talking about batters who have struck out at the plate, the leader is Reggie Jackson with 2,597 strikeouts.
Derek Jeter holds the all-time record for most strikeouts by a Yankees player.
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nolan Ryan
Jamie Moyer?
Nolan Ryan holds the career record with 5,714 strikeouts.
Mark Reynolds holds the record for most strikeouts in a single season with 223 strikeouts in 2009.
Matt Kilroy holds the record for most strikeouts by a pitcher in a single season with 513 in 1886. Nolan Ryan holds the modern day record with 383 in 1973.
actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
The most strikeouts by a pitcher in a World Series game is 17 by Bob Gibson of the St. Louis Cardinals in Game 1 of the 1968 World Series against the Detroit Tigers.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
bob gibson
Steve Carlton with 19 strikeouts on September 15, 1969 against the NY Nets.