actually Charles radbourn had 441 strikeouts but they still don't count that season there for Nolan Ryan holds the record with 383 strikeouts
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Sammy Sosa of the Cubs with 516 ... 174 in 1997 and 171 in both 1998 and 1999.
Buddy Scholtz had 26 strikeouts in a game for Miami University.
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That would be the great (seriously) Reggie Jackson who struck out 2597 times, more than 200 more times than second place, Sammy Sosa, who struck out 2306. Jackson is in the Hall of Fame, Sosa would have been if not for steroids but will most likely be voted in by the veterans committee.
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