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actually Charles radbourn had 441 strikeouts but they still don't count that season there for Nolan Ryan holds the record with 383 strikeouts

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13y ago

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More answers

Nolan Ryan, with 5,714 strikeouts, holds the career record.

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16y ago
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The most strikeouts in the MLB is currently held by Nolan Ryan. The next most is Randy Johnson. [2010]

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14y ago
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Matt Cain

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Wiki User

12y ago
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Nolan ryan

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Anonymous

4y ago
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Q: What is has the most strikeouts in Major League Baseball?
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