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actually Charles radbourn had 441 strikeouts but they still don't count that season there for Nolan Ryan holds the record with 383 strikeouts
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Earn +20 ptsQ: What is has the most strikeouts in Major League Baseball?
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Continue Learning about General History
What major league hitter had the most strikeouts in 1997 to 1999?
Sammy Sosa of the Cubs with 516 ... 174 in 1997 and 171 in both 1998 and 1999.
Who has the most college baseball game strikeouts in a single game?
Buddy Scholtz had 26 strikeouts in a game for Miami University.
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Who has struck out the most as a Major League Baseball hitter?
That would be the great (seriously) Reggie Jackson who struck out 2597 times, more than 200 more times than second place, Sammy Sosa, who struck out 2306. Jackson is in the Hall of Fame, Sosa would have been if not for steroids but will most likely be voted in by the veterans committee.
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