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Nolan Ryan with 5714. he had 300 strikeouts 6 times and almost 400 strikeouts. Nolan Ryan played a 28 year career.He led the American league in strikeouts 10 times.He has a record pitching a no hitter at 43 and 44 with 7 no hitters that's a record.

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13y ago

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Q: Who had the most strike outs?
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