Sandy Koufax' highest strikeout total for a single season was 382, in 1965.
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In Sandy's perfect game against the Cubs in 1965 he struckout 14 batters ... he struckout every batter he faced at least once except for Don Kessinger.
.180 - 24 for 133 with 1 HR, 10 RBIs, and 14 strikeouts. Groat's 133 at bats against Koufax tied Ernie Banks for the most at bats against Koufax in a career. Banks averaged .173 against Koufax with 7 HRs, 19 RBIs, and 31 strikeouts.
Johan Santana with 265 strikeouts in 2004.
Pitcher - Sandy Koufax, Los Angeles Dodgers - 382 Batter - Richie Allen, Philadelphia Phillies - 150
Sandy Koflax with 12
372 for the Arizona Diamondbacks in 2001.