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Buddy Scholtz had 26 strikeouts in a game for Miami University.
Randy Johnson - 19
The most strikeouts by a single pitcher in a single MLB game is 21 by Tom Cheney of the Washington Senators in a game against the Baltimore Orioles in 1962. The game lasted 16 innings and Cheney pitched all 16. The most strikeouts by a single pitcher in a 9 inning game is 20 and is held jointly by Kerry Wood, Randy Johnson, and Roger Clemens.
The Tigers team record for most strikeouts in a game by a pitcher is 16 by Mickey Lolich. He struckout 16 California Angels on May 23, 1969 and 16 Seattle Pilots on June 9, 1969.
No. The most strikeouts in a nine inning game is 20 by Randy Johnson, Roger Clemens, and Kerry Wood. That left 7 outs to be made by something other than a strikeout.