The top five are Derek Jeter with 96, Manny Ramirez with 86, Bernie Williams with 85, David Justice with 79 and Reggie Sanders with 79.
For the Los Angeles Angels single game records, the pitcher with the most strikeouts in one game of nine innings is Nolan Ryan with 19. The pitcher with the most strikeouts in a game with extra innings is also Nolan Ryan with 19. The pitcher with the most strikeouts in one inning is Chuck Finley with 4. The record for most strikeouts in a game by the team is 18. The player with the most strikeouts in one game while batting is Dallas McPherson with 4. The most strikeouts by a batter in a game with extra innings is Billy Cowan with 6.
Tom Cheney of the Washington Senators holds the MLB record for most strikeouts in a single game when he struckout 21 Baltimore Orioles batters in a 16 inning game in 1962. Kerry Wood, Randy Johnson, and Roger Clemens (twice) hold the MLB record for most strikeouts in a 9 inning game with 20. == ==
He was a famous major league left handed pitcher. He has the second most lifetime strikeouts of any left handed pitcher.
Nolan Ryan has the most career strikeouts with 5,714.
In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
Johan Santana with 265 strikeouts in 2004.
If you are talking about pitchers and who has the most K's, the answer is Nolan Ryan with 5,714 strikeouts. If you are talking about batters who have struck out at the plate, the leader is Reggie Jackson with 2,597 strikeouts.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.
Sandy Koufax with 382 strikeouts in 1965.
Whitey Ford has the most career World Strikeouts with 94.
Mark Reynolds holds the record for most strikeouts in a single season with 223 strikeouts in 2009.