Sandy Koufax with 382 strikeouts in 1965.
As of the 2010 season, the Yankees team record for strikeouts by a pitcher in a season is 248 by Ron Guidry in 1978.
In the modern era, the leader is Nolan Ryan, who had 383 strikeouts with the California Angels in 1973.
The Twins record for strikeouts in a game is 15 and held jointly by Camilo Pascual, Joe Decker, Jerry Koosman, and Bert Blyleven.
Nolan Ryan with 383 (modern record - in the 1800s teams only had one pitcher and some of those guys had 500+ strikeouts per season)
Matt Kilroy holds the record for most strikeouts by a pitcher in a single season with 513 in 1886. Nolan Ryan holds the modern day record with 383 in 1973.
Mickey Lolich with 308 in 1971.
Randy Johnson: Entering the 2008 season, he was 56 strikeouts behind Roger Clemens for second all time. Through his August 6th start against Pittsburgh, he had 114 strikeouts for the season, closing the gap to Nolan Ryan (1st all-time) to slightly under 1,000 strikeouts. http://www.enth.com/Home.aspx?q=what+pitcher+has+the+most+strikeouts
For the 2007 season, Jake Peavy of the San Diego Padres led all MLB pitchers in strikeouts with 240.
Nolan Ryan has the most career strikeouts in the history of baseball.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
Nolan Ryan has the most career strikeouts with 5,714. Randy Johnson has the 2nd most.
In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
The pitcher that had the most strikeouts in the 1960s was Bob Gibson. He had a total of 2,071, and he was also the best strikeout pitcher of the decade in the world series.
At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.
Nolan Ryan holds the record for most career strikeouts with 5.714.
Jim edmonds 167 strikeouts
actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
Nolan Ryan with 5,714 career strikeouts.