In MLB, that was J.R. Richard of the Houston Astros with 15 strikeouts in a 5-3 complete game victory over the San Francisco Giants on September 5, 1971.
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Randy Johnson - 19
Pitcher - Sandy Koufax, Los Angeles Dodgers - 382 Batter - Richie Allen, Philadelphia Phillies - 150
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
Johan Santana with 265 strikeouts in 2004.
The Tigers team record for most strikeouts in a game by a pitcher is 16 by Mickey Lolich. He struckout 16 California Angels on May 23, 1969 and 16 Seattle Pilots on June 9, 1969.