Nolan Ryan has the most career strikeouts with 5,714. Randy Johnson has the 2nd most.
15 strikeouts by j.r. Richard f the Houston astros
In 1984, Dwight Gooden set the record (which he still holds) for strikeouts by a rookie pitcher, with 276 K's.
For the 2007 season, Jake Peavy of the San Diego Padres led all MLB pitchers in strikeouts with 240.
In MLB, 21 by Tom Cheney of the Washington Senators in a 16 inning complete game, 2-1 victory, against the Baltimore Orioles on September 12, 1962. Cheney's 21 strikeouts is an MLB record for strikeouts in a game by a pitcher. Several MLB pitchers have struckout 20 batters in a game (all of which were 9 inning games) but no MLB pitcher has struckout more batters in a game than Cheney. For the record, Cheney had 13 strikeouts through 9 innings.
Tom Cheney of the Washington Senators holds the MLB record for most strikeouts in a single game when he struckout 21 Baltimore Orioles batters in a 16 inning game in 1962. Kerry Wood, Randy Johnson, and Roger Clemens (twice) hold the MLB record for most strikeouts in a 9 inning game with 20. == ==
Nolan Ryan has the most career strikeouts with 5,714.
Nolan Ryan holds the career MLB strikeout record with 5,714.
Randy Johnson: Entering the 2008 season, he was 56 strikeouts behind Roger Clemens for second all time. Through his August 6th start against Pittsburgh, he had 114 strikeouts for the season, closing the gap to Nolan Ryan (1st all-time) to slightly under 1,000 strikeouts. http://www.enth.com/Home.aspx?q=what+pitcher+has+the+most+strikeouts