Through games played on September 26, 2007 the Giants franchise has won the most MLB games with 10,183. The Cubs are second at 9,983.
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It's a tie at 21 games. The 1880 Chicago White Stockings and the 1935 Chicago Cubs both achieved 21 consecutive victories. Source: Baseball-almanac.com
The 1976, Miami Dolpins won 18 regular season games and the Super Bowl. The 2007 Patriots won 18 games, but lost the super bowl.