Regular Season the Colts do
The Miami Dolphins
Through the 2013 season, the Arizona Cardinalshave the most losses in NFL history, with 723. Regular season (716), playoffs (7).
Green Bay Packers
The Chicago Bears have the most victories in NFL history. They are 744-568-42.
Between 1970-1979, the Dallas Cowboys had the most regular season wins in the NFL with 105. The Miami Dolphins were second with 104 regular season wins.
As of as of March 8, 2012 The NFL team who has the most regular season wins since 1970 are the Pittsburgh Steelers with 396 regular wins since 1970.