Here's the all-time list as of the start of the 2008 season:
CAREER
STRIKEOUTS SO
1 Frank White 1035
2 Willie Wilson 990
3 Amos Otis 953
4 George Brett 908
5 Hal McRae 697
6 Bo Jackson 638
7 Danny Tartabull 592
8 Freddie Patek 586
9 Carlos Beltran 584
10 Steve Balboni 568
11 Mike Sweeney 555
12 Mike Macfarlane 536
13 Joe Randa 497
14 John Mayberry 457
15 Angel Berroa 407
16 Brian McRae 388
17 Jermaine Dye 383
18 Johnny Damon 350
19 John Buck 349
20 U.L. Washington 346
21 Kevin Seitzer 326
22 Mark Teahen 319
23 Michael Tucker 313
T24 Bob Oliver 300
T24 Brent Mayne 300
26 Carlos Febles 297
27 Al Cowens 286
28 David DeJesus 284
29 Willie Aikens 280
30 Emil Brown 274
T31 Ed Kirkpatrick 265
T31 John Wathan 265
T31 Lou Piniella 265
34 Dave Howard 262
35 Darrell Porter 260
36 Jose Offerman 258
37 Kurt Stillwell 256
38 Jamie Quirk 249
39 Cookie Rojas 236
40 Greg Gagne 232
41 Gary Gaetti 229
42 Paul Schaal 226
43 Wally Joyner 225
44 Matt Stairs 213
45 Jim Eisenreich 210
46 Raul Ibanez 208
47 Dee Brown 205
48 Tom Goodwin 203
49 Ken Harvey 200
50 Aaron Guiel 198
51 Pat Sheridan 194
52 Bob Hamelin 191
T53 Clint Hurdle 186
T53 Mark Quinn 186
T55 Darryl Motley 184
T55 Dean Palmer 184
T57 Felix Jose 179
T57 Jeff King 179
59 Lonnie Smith 178
60 Pat Kelly 175
61 Tony Solaita 166
62 Fran Healy 163
63 Jackie Hernandez 161
T64 Jim Sundberg 158
T64 Craig Paquette 158
66 Bill Pecota 155
67 Gary Thurman 154
68 Jim Wohlford 153
69 Terry Shumpert 150
70 Dick Drago 149
T71 Jerry Martin 145
T71 Buddy Biancalana 145
73 Buck Martinez 144
74 Joe Vitiello 142
T75 Rey Sanchez 137
T75 Alex Gordon 137
77 Mark Grudzielanek 129
78 Desi Relaford 126
79 Dave McCarty 123
80 Vince Coleman 120
81 Phil Hiatt 119
82 Jon Nunnally 118
83 Sal Fasano 110
T84 Jorge Orta 109
T84 Esteban German 109
T86 Pat Tabler 104
T86 Kevin McReynolds 104
T88 Kirk Gibson 103
T88 Ryan Shealy 103
T90 Reggie Sanders 101
T90 Jay Bell 101
92 Tony Graffanino 97
T93 Chili Davis 96
T93 Jeff Conine 96
95 Don Slaught 94
T96 Onix Concepcion 93
T96 Angel Salazar 93
98 Bip Roberts 91
99 Luis Alicea 90
100 Pete LaCock 88
T101 Mike Fiore 87
T101 Ruben Gotay 87
T103 Mendy Lopez 82
T103 Greg Pryor 82
105 Joey Gathright 81
106 Tim Spehr 80
107 Bill Butler 79
T108 Jose Lind 78
T108 Tony Pena Jr. 78
110 Bobby Floyd 77
111 Jeremy Giambi 76
T112 Larry Sutton 75
T112 Joe Foy 75
T114 Larry Owen 74
T114 Tom Poquette 74
T116 Keith Miller 72
T116 Neifi Perez 72
118 Harmon Killebrew 70
T119 Vada Pinson 66
T119 Jason LaRue 66
T119 Shane Halter 66
122 Chad Kreuter 65
T123 Jed Hansen 64
T123 Joe Keough 64
T125 Jim Rooker 63
T125 Shane Costa 63
T125 Steve Hovley 63
T128 Mike Hedlund 62
T128 Kurt Bevacqua 62
T130 Keith Lockhart 61
T130 Ellie Rodriguez 61
T130 A.J. Hinch 61
133 Brad Wellman 59
134 Bob Stinson 58
T135 Calvin Pickering 56
T135 Gerald Perry 56
T135 Terrence Long 56
T138 Billy Butler 55
T138 Jerry May 55
140 Curtis Wilkerson 53
T141 Hal Morris 52
T141 Bobby Knoop 52
T143 Gregg Zaun 50
T143 Doug Mientkiewicz 50
T145 Terry Pendleton 49
T145 Yamil Benitez 49
T145 Carl Taylor 49
T145 Bob Boone 49
T149 Abraham Nunez 48
T149 Richie Scheinblum 48
T151 Todd Benzinger 46
T151 Paul Bako 46
T153 Cesar Geronimo 45
T153 Joe Zdeb 45
T153 Brandon Berger 45
156 Chris Gwynn 44
T157 Rey Palacios 42
T157 Todd Dunwoody 42
159 Wally Bunker 41
160 George Spriggs 40
T161 Jerry Adair 39
T161 Chuck Harrison 39
T161 Ross Gload 39
T164 Rich Severson 38
T164 Juan Samuel 38
T164 Rod Myers 38
T164 Butch Davis 38
T168 Roger Nelson 37
T168 Hubie Brooks 37
T168 Dave Nelson 37
T171 Shane Mack 36
T171 Dennis Paepke 36
T173 Scott Pose 35
T173 Joe McEwing 35
T175 Hawk Taylor 34
T175 Bob Johnson 34
T177 Bruce Dal Canton 33
T177 Jim Campanis 33
T179 Scott Cooper 32
T179 George Scott 32
T179 Jeff Reboulet 32
T179 Lee May 32
T179 Gail Hopkins 32
T179 Kevin Young 32
T179 Hector Ortiz 32
T179 Chip Ambres 32
T179 Thad Bosley 32
T179 Benito Santiago 32
T179 Chuck Knoblauch 32
T190 Dane Iorg 31
T190 Rico Rossy 31
T190 Alberto Castillo 31
T190 Luis Ordaz 31
T194 Leon Roberts 30
T194 Donnie Murphy 30
T194 Bill Buckner 30
T194 Mike Kingery 30
T194 Mike DiFelice 30
T199 Steve Braun 29
T199 Al Fitzmorris 29
T199 Kevin Koslofski 29
T199 Donnie Sadler 29
T199 Dave Chalk 29
T199 Lynn Jones 29
T199 Jason Smith 29
T199 Gregg Jefferies 29
T199 Felix Martinez 29
T208 Brian Johnson 28
T208 Rick Reichardt 28
T208 Dave Henderson 28
T208 Sean Berry 28
212 Wilson Delgado 27
T213 Justin Huber 26
T213 Harvey Pulliam 26
T213 Juan Beniquez 26
T216 Carmelo Martinez 25
T216 Andres Blanco 25
218 Steve Scarsone 24
T219 Matt Winters 23
T219 Tommy Matchick 23
T221 Rudy Law 22
T221 Ray Holbert 22
T221 Pat Borders 22
T221 Luis Alcaraz 22
T225 Joe Simpson 21
T225 Steve Jeltz 21
T225 Kit Pellow 21
T228 Tom Burgmeier 20
T228 Ruben Mateo 20
T228 Les Norman 20
T231 Todd Cruz 19
T231 Juan Rios 19
T231 Juan Gonzalez 19
T231 Scott Northey 19
T235 Luis delosSantos 18
T235 Steve Hammond 18
T235 Warren Cromartie 18
T235 Eli Marrero 18
T239 Rance Mulliniks 17
T239 Joe Lahoud 17
T239 Luis Rivera 17
T239 Jermaine Allensworth 17
T243 Dave Morehead 16
T243 Kelly Stinnett 16
T243 Paul Splittorff 16
T243 Orlando Cepeda 16
T243 Ruppert Jones 16
T248 Ted Abernathy 15
T248 Jeff Schulz 15
T248 Ken Phelps 15
T248 Ross Jones 15
T248 Paul Phillips 15
T248 Edgar Caceres 15
T248 Matt Diaz 15
T255 Byron Gettis 14
T255 Jerry Terrell 14
T255 Scott Leius 14
T255 Henry Mercedes 14
T255 Ken Wright 14
T260 Bob Melvin 13
T260 Bill Sorrell 13
T260 Monty Montgomery 13
T263 Jose Bautista 12
T263 Julius Matos 12
265 Jorge Fabregas 11
T266 Chris James 10
T266 Fred Rico 10
T266 Alexis Gomez 10
T266 Denny Hocking 10
T266 Patrick Lennon 10
T266 Scotti Madison 10
272 Ernie Young 9
T273 Chris Stynes 8
T273 Bob Heise 8
T273 Moe Drabowsky 8
T273 Jim York 8
T273 Russ Morman 8
T273 Omar Moreno 8
T273 Endy Chavez 8
T273 Rondell White 8
T281 Brent Cookson 7
T281 Jeff Grotewold 7
T281 Chris Hatcher 7
T281 Rusty Torres 7
T281 Kerry Robinson 7
T286 Jeff Keppinger 6
T286 Dan Reichert 6
T286 Craig Wilson 6
T286 Jarrod Patterson 6
T286 Kevin Appier 6
T286 Frank Ortenzio 6
T286 Damian Jackson 6
T286 Ron Hansen 6
T286 Ted Savage 6
T286 Jay Witasick 6
T286 Mike Brewer 6
T297 Darrell May 5
T297 Jorge Pedre 5
T297 Jose Cardenal 5
T297 Jose Rosado 5
T297 Donzell McDonald 5
T297 Sandy Valdespino 5
T303 Shawn Sedlacek 4
T303 Paul Byrd 4
T303 Art Kusnyer 4
T303 Keith Marshall 4
T303 Mitch Maier 4
T303 Wilton Guerrero 4
T303 Angel Sanchez 4
T303 Bob Detherage 4
T303 Chris Turner 4
T303 Dave Leeper 4
T303 Ron Johnson 4
T303 Mike Jackson 4
T303 Fernando Gonzalez 4
T316 Jim Pittsley 3
T316 Mac Suzuki 3
T316 Jeff Suppan 3
T316 Nick Capra 3
T316 Ryan Long 3
T316 Cliff Pastornicky 3
T316 Rondin Johnson 3
T316 Rodney Scott 3
T316 Mark Ryal 3
T316 Steve Busby 3
T316 Tom Murphy 3
T316 Ed Hearn 3
T316 Miguel Batista 3
T316 Juan Brito 3
T316 Dave Owen 3
T316 Tim Belcher 3
T316 Luis Silverio 3
T316 Jim Gaudet 3
T316 Dennys Reyes 3
T316 Brent Abernathy 3
In his 21 year Major League Baseball (MLB) career, Reggie Jackson holds MLB record for most career strikeouts by a player/batter, with a career total of 2,597 strikeouts - 46 times while with the Kansas City Royals, 1,180 with the Oakland Athletics, 108 with the Baltimore Orioles, 573 times with the New York Yankees, and 690 times with the California Angels.
Whitey Ford has the most career World Strikeouts with 94.
Tom Cheney of the Washington Senators holds the MLB record for most strikeouts in a single game when he struckout 21 Baltimore Orioles batters in a 16 inning game in 1962. Kerry Wood, Randy Johnson, and Roger Clemens (twice) hold the MLB record for most strikeouts in a 9 inning game with 20. == ==
Mickey Mantle is second on the all-time Yankees list for most strikeouts, with 1,710. Derek Jeter is first.
Nolan Ryan holds the career record with 5,714 strikeouts.
Derek Jeter holds the all-time record for most strikeouts by a Yankees player.
Hall of Fame pitcher Walter Johnson retired in 1927 with 3,508 career strikeouts, the MLB record. Ryan broke that record in 1983 and went on to strikeout a total of 5,714 batter during his career, a record that will be around for a long time.
Nolan Ryan struckout 5,714 batters in a career that spanned 1966, 1968-1993.
As of the 2010 season, the Yankees team record for strikeouts by a pitcher in a season is 248 by Ron Guidry in 1978.
Sammy Sosa with 174 in 1997.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
In MLB, through the 2008 season: Pitcher: Nolan Ryan of the California Angels struckout 383 batters in 1973. Batter: Mark Reynolds of the Arizona Diamondbacks holds the MLB record for striking out in a season with 204 strikeouts in 2008.