Here's the all-time list as of the start of the 2008 season:
CAREER
STRIKEOUTS SO
1 Tony Perez 1306
2 Johnny Bench 1278
3 Dave Concepcion 1186
4 Adam Dunn 1092
5 Pete Rose 972
6 George Foster 882
7 Eric Davis 874
8 Vada Pinson 831
9 Barry Larkin 817
10 Frank Robinson 789
11 Reggie Sanders 777
12 Leo Cardenas 728
13 Ron Oester 681
14 Cesar Geronimo 662
15 Jason LaRue 645
16 Dan Driessen 639
17 Ken Griffey Jr. 609
18 Lee May 597
19 Wally Post 593
20 Nick Esasky 581
21 Ken Griffey Sr. 549
22 Hal Morris 467
23 Sean Casey 465
24 Bret Boone 463
25 Paul O'Neill 456
26 Gus Bell 452
27 Roy McMillan 444
28 Joe Oliver 437
29 Aaron Boone 428
30 Billy Myers 420
31 Eddie Taubensee 414
32 Austin Kearns 412
33 Joe Morgan 410
34 Chris Sabo 408
35 Dave Parker 399
36 Tommy Harper 397
37 Deron Johnson 386
38 Bobby Adams 384
39 Johnny Edwards 371
40 Pokey Reese 359
41 Grady Hatton 356
42 Ed Bailey 355
43 Ival Goodman 345
T44 Willie Greene 342
T44 Bobby Tolan 342
46 Gordy Coleman 331
47 Dmitri Young 322
48 Felipe Lopez 317
49 Lonny Frey 306
50 Ryan Freel 305
51 Ted Kluszewski 292
52 Wily Mo Pena 288
53 Bob Bescher 282
54 Greasy Neale 272
55 Jeff Branson 264
56 Bob Purkey 263
57 Heine Groh 257
58 Gary Redus 255
59 Darrel Chaney 253
60 Eddie Milner 247
61 Juan Castro 244
62 Dave Collins 231
63 Bid McPhee 229
64 Alex Kampouris 226
T65 Johnny Temple 225
T65 Johnny Wyrostek 225
67 Edwin Encarnacion 224
68 Jerry Lynch 215
69 Kal Daniels 214
T70 Gary Nolan 211
T70 Bug Holliday 211
72 Todd Benzinger 209
73 Tommy Helms 206
74 Eddie Miller 205
75 Harry Craft 203
76 Ray Knight 201
T77 Tom Browning 200
T77 Michael Tucker 200
T79 Brandon Phillips 197
T79 Jim O'Toole 197
81 Johnny Vander Meer 192
82 Bo Diaz 191
83 Andy Seminick 189
84 Ken Raffensberger 187
85 Jim Greengrass 185
86 Eddie Kasko 184
87 Cesar Cedeno 183
88 Joe Nuxhall 181
89 Mariano Duncan 179
90 Germany Smith 178
91 Tommy Clarke 177
T92 Arlie Latham 176
T92 Eddie Joost 176
T92 Virgil Stallcup 176
95 Ivy Wingo 175
96 Chick Hafey 174
97 Don Pavletich 172
98 Bill Plummer 171
99 Edd Roush 170
100 Paul Householder 169
101 Gee Walker 168
T102 Ray Mueller 167
T102 David Ross 167
104 Mario Soto 166
105 D'Angelo Jimenez 165
106 Pat Duncan 163
107 Paul Derringer 162
108 Ernie Lombardi 158
109 Curt Walker 157
110 Doc Hoblitzell 156
111 Russ Branyan 155
112 Duane Walker 154
113 Ray Lamanno 151
T114 Frank McCormick 149
T114 Bert Haas 149
116 Herm Winningham 148
T117 Reggie Taylor 147
T117 Joey Jay 147
T117 Bubbles Hargrave 147
120 Aaron Harang 146
121 Mike Cameron 145
122 Bucky Walters 144
T123 Jack Billingham 143
T123 Hod Ford 143
T125 George Crowe 141
T125 Chico Ruiz 141
T127 Alex Johnson 140
T127 Marty Keough 140
T129 Sammy Bohne 139
T129 Thomas Howard 139
T129 George Kelly 139
T132 Babe Pinelli 138
T132 Bernie Carbo 138
T132 Jim Maloney 138
T135 Kelly Stinnett 137
T135 Glenn Braggs 137
T135 Greg Vaughn 137
138 Kiki Cuyler 135
T139 Eppa Rixey 134
T139 Morgan Murphy 134
T141 Mike Mitchell 133
T141 Jeff Reed 133
143 Fred Norman 132
144 Rube Bressler 131
T145 Deion Sanders 130
T145 Tom Seaver 130
T145 Eduardo Perez 130
T145 Dain Clay 130
T149 Hughie Critz 129
T149 Denis Menke 129
151 Gene Freese 128
T152 Dick Egan 127
T152 Larry Kopf 127
T152 Javier Valentin 127
T155 Hank Sauer 126
T155 Kevin Mitchell 126
T155 Ike Caveney 126
T155 Jake Daubert 126
159 Tommy Griffith 124
160 Todd Walker 123
T161 Johnny Bates 122
T161 Leo Durocher 122
T163 Rolando Roomes 120
T163 John Reilly 120
165 Eric Tipton 119
T166 Buddy Bell 118
T166 Lew Riggs 118
T166 Rich Aurilia 118
T166 Connie Ryan 118
T170 Luis Quinones 117
T170 Rube Benton 117
172 Chris Stynes 116
173 Lenny Harris 115
T174 Bob Borkowski 114
T174 Chuck Dressen 114
T176 Al Libke 112
T176 Hal Chase 112
T176 Bob Thurman 112
T176 Woody Woodward 112
180 Si Johnson 111
T181 Sammy Ellis 110
T181 Jim Keenan 110
T181 Bill Werber 110
184 Danny Litwhiler 109
T185 Art Shamsky 108
T185 Ron Gant 108
T185 Billy Hatcher 108
T185 Wally Berger 108
189 Babe Herman 106
190 George Burns 105
191 Fred Toney 104
T192 Lloyd Merriman 103
T192 Bob Usher 103
194 Junior Kennedy 102
T195 Don Gullett 101
T195 Jose Rijo 101
T197 Max Marshall 100
T197 Bip Roberts 100
Tom Cheney of the Washington Senators holds the MLB record for most strikeouts in a single game when he struckout 21 Baltimore Orioles batters in a 16 inning game in 1962. Kerry Wood, Randy Johnson, and Roger Clemens (twice) hold the MLB record for most strikeouts in a 9 inning game with 20. == ==
Mickey Mantle is second on the all-time Yankees list for most strikeouts, with 1,710. Derek Jeter is first.
Whitey Ford has the most career World Strikeouts with 94.
Derek Jeter holds the all-time record for most strikeouts by a Yankees player.
Nolan Ryan holds the career record with 5,714 strikeouts.
As of the 2010 season, the Yankees team record for strikeouts by a pitcher in a season is 248 by Ron Guidry in 1978.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
Nolan Ryan has the most career strikeouts with 5,714.
Sammy Sosa with 174 in 1997.
actually Charles radbourn had 441 strikeouts but they still don't count that season there for nolan Ryan holds the record with 383 strikeouts
The most strikeouts by a pitcher in a World Series game is 17 by Bob Gibson of the St. Louis Cardinals in Game 1 of the 1968 World Series against the Detroit Tigers.
In his 21 year Major League Baseball (MLB) career, Reggie Jackson holds MLB record for most career strikeouts by a player/batter, with a career total of 2,597 strikeouts - 46 times while with the Kansas City Royals, 1,180 with the Oakland Athletics, 108 with the Baltimore Orioles, 573 times with the New York Yankees, and 690 times with the California Angels.