The only Boston Red Sox pitcher to throw a perfect game was Cy Young on May 4, 1904. The Red Sox won the game 3-0 over Philadelphia.
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There is only one perfect or no-hitter game in World Series history. This perfect was pitched by Don Larsen in the 5th game of the 1956 World Series.
In MLB, that was Lee Richmond of the Worcester Ruby Legs against the Cleveland Blues on June 12, 1880.