Ussually in a league game there are 6 or 7 substitute players but only 3 of them may enter the pitch during a league game.
In a friendly there can be a maximum of 12 substitute players and the number of substitues a coach can make is unlimited.
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The maximum number of subs allowed in most competitive matches, including domestic leagues/cups and internationals is three.
Friendly matches and other competitions can vary the number.
Seven. How many you can use depends on the type of competition. Unlimited for friendlies, 3 for competitive matches.