Disabilities can and will affect vision, reaction time, and hand-eye co-ordination. But, most athletes have overcome their disabilities and don't talk about it. Mahmoud Abdul-Rauf (Denver Nuggets Point Guard 1990-1995) overcame Tourette syndrome and no one knew about it.
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It depends what kind of disability.My dad is in a wheel chair and he can't play sports,but if it is a men-tel disability than you could probably play sports but need help.