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Through the 2008 regular season, once. That was September 10, 2006 when the Peyton and the Colts defeated Eli and the Giants, 26-21. Peyton completed 25 passes in 41 attempts for 276 yards, 1 TD, and 1 INT and Eli completed 20 passes in 34 attempts for 247 yards, 2 TDs, and 1 INT.

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