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Babe Ruth was the first player to hit three home runs in a World Series game in Game 4 of the 1926 World Series against the St. Louis Cardinals. In addition, Ruth hit three home runs in Game 4 of the 1928 World Series, also against the St. Louis Cardinals. Reggie Jackson hit three home runs in Game 6 of the 1977 World Series against the Los Angeles Dodgers.

On October 22, 2011, Albert Pujols of the St. Louis Cardinals added his name to the list with three home runs in Game 3 of the World Series at Arlington, Texas. The St. Louis Cardinals first baseman hit a three-run homer in the sixth inning, a two-run shot in the seventh and a solo dinger in the ninth to pace the Cards to a 16-7 victory over the Texas Rangers.

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