The team with the most home runs in the 2010 MLB season is the Toronto Blue Jays. As of September 25, 2010 they have 241 home runs. This includes the total of the major league leader Jose Bautista, who has belted 52 through 155 games.
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Through games played on July 26, 2009 that is the New York Yankees with 144. The Texas Rangers are second with 143 and the Philadelphia Phillies are third with 138.
During the 2011 Major League Baseball (MLB) regular season, the New York Yankees hit the most home runs, with a team total of 222.
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In 1997, the Seattle Mariners hit 264 home runs to set the MLB record.
Yankees hit 108 home runs on the road in the regular season this season, second only to Philadelphia.
If you mean by an individual player, the answer is Barry Bonds: 73 home runs in 2001. The American League record is still owned by Roger Maris, who hit 61 home runs in 1961. If you mean by a team, that record was set by the Seattle Mariners in 1997 with 264 home runs. If you mean the highest single-season major league total, the most home runs hit in the major leagues in a single season occurred in 2000, with 5,693.