If you mean by an individual player, the answer is Barry Bonds: 73 home runs in 2001. The American League record is still owned by Roger Maris, who hit 61 home runs in 1961.
If you mean by a team, that record was set by the Seattle Mariners in 1997 with 264 home runs.
If you mean the highest single-season major league total, the most home runs hit in the major leagues in a single season occurred in 2000, with 5,693.
The most home runs in a single season is 73 by Barry Bonds in 2001. Bonds played for the Pittsburgh Pirates from 1986-1992, and the San Francisco Giants from 1993-2007.
Jeff Kent holds the record for the most Homeruns hit as a 2nd basemen, he hit 351 Homeruns while playing 2nd base for the Mets, the Giants, the Astros and the Dodgers.
Albert Pujols, who also hit 14 homeruns in the month of April the year before.
He has hit 762 homeruns which is the record
Bernie Williams has hit the most postseason homeruns for the Yankees with 22. Mickey Mantle has hit the most World Series homeruns in baseball history with 18.
3,875,132,857 homeruns have been hit. 3,875,132,857 homeruns have been hit.
Ivan Rodriguez:he has hit 309 homeruns and has the most homeruns for a cather
Jeff Kent holds the record for the most Homeruns hit as a 2nd basemen, he hit 351 Homeruns while playing 2nd base for the Mets, the Giants, the Astros and the Dodgers.
Albert Pujols, who also hit 14 homeruns in the month of April the year before.
He has hit 762 homeruns which is the record
Bernie Williams has hit the most postseason homeruns for the Yankees with 22. Mickey Mantle has hit the most World Series homeruns in baseball history with 18.
Mike Napoli, Nelson Cruz, and Adraian Beltre each hit 2 homeruns, which tied them for the player to hit the most homeruns for the Rangers in the World Series.
It's Alex Rodriguez With the NY Yankees. he hit 54.
Hit it hard
3,875,132,857 homeruns have been hit. 3,875,132,857 homeruns have been hit.
A-Rod is the youngest player to hit 500 Homeruns. Go Yankees!
2001 He hit 37 homeruns while driving 130 RBI'S and winning the rookie of the year.
As of July 25th 2012 he's at 99 homeruns!