Carmelo Castillo debuted on July 17, 1982, playing for the Cleveland Indians at Cleveland Stadium; he played his final game on May 9, 1991, playing for the Minnesota Twins at Hubert H Humphrey Metrodome.
Francisco Melendez debuted on August 26, 1984, playing for the Philadelphia Phillies at Veterans Stadium; he played his final game on October 1, 1989, playing for the Baltimore Orioles at Memorial Stadium.
Luis Castillo debuted on August 8, 1996, playing for the Florida Marlins at Joe Robbie Stadium; he played his final game on October 3, 2010, playing for the New York Mets at Citi Field.
Luis Aponte debuted on September 4, 1980 and played his final game on July 6, 1984.
Wilkin Castillo debuted on September 2, 2008, playing for the Cincinnati Reds at Great American Ball Park; he played his final game on June 20, 2009, playing for the at .
Frank Castillo debuted on June 27, 1991, playing for the Chicago Cubs at Wrigley Field; he played his final game on May 26, 2005, playing for the Florida Marlins at Dolphin Stadium.
Manny Castillo debuted on September 1, 1980, playing for the Kansas City Royals at Royals Stadium; he played his final game on October 2, 1983, playing for the Seattle Mariners at Kingdome.
Bobby Cargo debuted on October 6, 1892 and played his final game on October 7, 1892.
Jose Cabrera debuted on July 15, 1997 and played his final game on September 25, 2002.
Alberto Castillo debuted on May 28, 1995 and played his final game on June 21, 2007.
Braulio Castillo debuted on August 18, 1991 and played his final game on October 4, 1992.
Carmelo Castillo debuted on July 17, 1982 and played his final game on May 9, 1991.
Frank Castillo debuted on June 27, 1991 and played his final game on May 26, 2005.
Juan Castillo debuted on April 12, 1986 and played his final game on April 17, 1989.
Lendy Castillo debuted on April 9, 2012 and played his final game on September 29, 2012.
Manny Castillo debuted on September 1, 1980 and played his final game on October 2, 1983.
Marty Castillo debuted on August 19, 1981 and played his final game on October 5, 1985.
Tony Castillo debuted on September 22, 1978 and played his final game on October 1, 1978.
Welington Castillo debuted on August 11, 2010 and played his final game on September 19, 2013.
Wilkin Castillo debuted on September 2, 2008 and played his final game on June 20, 2009.