Luis Aponte debuted on September 4, 1980 and played his final game on July 6, 1984.
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Luis Gonzalez debuted on September 4, 1990, playing for the Houston Astros at Astrodome; he played his final game on September 28, 2008, playing for the Florida Marlins at Dolphin Stadium.
Luis Atilano debuted on April 23, 2010, playing for the Washington Nationals at Nationals Park; he played his final game on July 20, 2010, playing for the Washington Nationals at Nationals Park.
Luis Avilan debuted on July 14, 2012, playing for the Atlanta Braves at Turner Field; he played his final game on September 29, 2013, playing for the Atlanta Braves at Turner Field.
Luis Garcia debuted on April 5, 1999, playing for the Detroit Tigers at Tiger Stadium; he played his final game on May 3, 1999, playing for the Detroit Tigers at Tiger Stadium.
Luis Tiant debuted on July 19, 1964, playing for the Cleveland Indians at Cleveland Stadium; he played his final game on September 4, 1982, playing for the California Angels at Anaheim Stadium.