Frank Castillo debuted on June 27, 1991, playing for the Chicago Cubs at Wrigley Field; he played his final game on May 26, 2005, playing for the Florida Marlins at Dolphin Stadium.
Frank Castillo played in 14 games at pitcher for the Colorado Rockies in 1997, starting in all of them. He played for a total of 259 outs, equivalent to 9.59 9-inning games. He made no putouts, had 9 assists, and committed no errors, equivalent to 0 errors per 9-inning game. He had one double play.
Wilkin Castillo debuted on September 2, 2008, playing for the Cincinnati Reds at Great American Ball Park; he played his final game on June 20, 2009, playing for the at .
Frank Abercrombie debuted on October 21, 1871 and played his final game on October 21, 1871.
Frank Allen debuted on April 24, 1912 and played his final game on September 19, 1917.
Frank Bahret debuted on April 17, 1884 and played his final game on April 22, 1884.
Frank Castillo debuted on June 27, 1991 and played his final game on May 26, 2005.
Alberto Castillo debuted on May 28, 1995 and played his final game on June 21, 2007.
Braulio Castillo debuted on August 18, 1991 and played his final game on October 4, 1992.
Carmelo Castillo debuted on July 17, 1982 and played his final game on May 9, 1991.
Carlos Castillo debuted on April 2, 1997 and played his final game on July 22, 2001.
Juan Castillo debuted on April 12, 1986 and played his final game on April 17, 1989.
Lendy Castillo debuted on April 9, 2012 and played his final game on September 29, 2012.
Manny Castillo debuted on September 1, 1980 and played his final game on October 2, 1983.
Marty Castillo debuted on August 19, 1981 and played his final game on October 5, 1985.
Tony Castillo debuted on September 22, 1978 and played his final game on October 1, 1978.
Welington Castillo debuted on August 11, 2010 and played his final game on September 19, 2013.
Wilkin Castillo debuted on September 2, 2008 and played his final game on June 20, 2009.