Randy Johnson - 19
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Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
Johan Santana with 265 strikeouts in 2004.
The Tigers team record for most strikeouts in a game by a pitcher is 16 by Mickey Lolich. He struckout 16 California Angels on May 23, 1969 and 16 Seattle Pilots on June 9, 1969.
In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.