Since ERA is calculated by dividing by innings pitched, if a pitcher fails to record an out, his ERA will be infinity. This has probably happened over a thousand times.
The next best answer is: On 8/13/2006, Kansas City's Luke Hudson pitched 1/3 of an inning and allowed 10 ER against the Indians, for a one-game ERA of 270.00!
Link to the boxscore:
http://www.Baseball-reference.com/boxes/CLE/CLE200608130.shtml
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Today a pitcher in the Royals Tigers game a reliever had an era of 90.
^^ They change from game to game, but the Highest one I have ever seen was by Peter Moylan of the Atlanta Braves, after he pitched against the Phillies. He came on the next day and his ERA was 135.00.
The major league pitcher with the highest ERA in a single season who pitched 100 or more innings was Bill Chamberlain. He recorded an ERA of 7.74 in the 1893 season while playing for the St. Louis Browns.
Pedro Martinez of the Boston Red Sox led MLB in ERA in 2003 with 2.22.
Which era marks the highest level of cultural development of ancient people?
John Van Benschoten of the Pittsburgh Pirates has the highest career ERA in major league history of any pitcher with at least 75 innings pitched. His whopping 9.20 ERA is unparalleled, earning him MLB glory which will certainly earn him a spot in the Hall of Fame.
the 1930 Philadelphia Phillies had a combined team ERA of 6.71. the team's overall record was 52-102. the 2nd highest team era was by the 1996 Detroit Tigers who had an ERA of 6.38 and a record of 53-109