John Van Benschoten of the Pittsburgh Pirates has the highest career ERA in major league history of any pitcher with at least 75 innings pitched. His whopping 9.20 ERA is unparalleled, earning him MLB glory which will certainly earn him a spot in the Hall of Fame.
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The major league pitcher with the highest ERA in a single season who pitched 100 or more innings was Bill Chamberlain. He recorded an ERA of 7.74 in the 1893 season while playing for the St. Louis Browns.
Since ERA is calculated by dividing by innings pitched, if a pitcher fails to record an out, his ERA will be infinity. This has probably happened over a thousand times. The next best answer is: On 8/13/2006, Kansas City's Luke Hudson pitched 1/3 of an inning and allowed 10 ER against the Indians, for a one-game ERA of 270.00! Link to the boxscore: http://www.baseball-reference.com/boxes/CLE/CLE200608130.shtml
Which era marks the highest level of cultural development of ancient people?
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Pedro Martinez of the Boston Red Sox led MLB in ERA in 2003 with 2.22.