I would say 73 points since the Chicago Bears beat the Washington Redskins 73-0 in an NFL Championship game on December 8th, 1940. Not only did Chicago kill the Redskins but they also set a record for most points in a game set by one team so 73 points has to be the biggest score differential in an NFL game.
25
73-0 in 1940
Yes
Leading a game 21 points ahead
I don't remember a game with a score of 72-0 but there was a game with the score of 73-0. This was in the 1940 NFL Championship game between the Chicago Bears and the Washington Redskins. The Bears won the game 73-0.
The worst point differential in NFL history occurred in a game between the Chicago Bears and the Washington Redskins on December 8, 1940. The Bears won the game with a score of 73-0, resulting in a point differential of 73 points.
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The score of a forfeited NFL game is 2-0. The reasoning behind this is that a safety is the only way to score in an NFL game in which no points are credited to a specific player. There has only been 1 official forfeit in NFL history (1920 - Rochester Jeffersons lost by forfeit to the Washington Pros/Senators).
The Patriots' 45-point lead at intermission against the Titans (45-0) on Oct. 18, 2009 was the largest halftime lead in NFL history, surpassing the previous mark of 42 when the Packers led the Buccaneers, 49-7, on Oct. 2, 1983.
73-0 in 1940
Yes
When an NFL team doesn't score a single point in a game, that is called a shutout.
Leading a game 21 points ahead
no da
Approx. 90 Points
The game is over.
In 1943 the Giants and Lions ended the game 0 to 0