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I would say 73 points since the Chicago Bears beat the Washington Redskins 73-0 in an NFL Championship game on December 8th, 1940. Not only did Chicago kill the Redskins but they also set a record for most points in a game set by one team so 73 points has to be the biggest score differential in an NFL game.
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73-0 in 1940
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I don't remember a game with a score of 72-0 but there was a game with the score of 73-0. This was in the 1940 NFL Championship game between the Chicago Bears and the Washington Redskins. The Bears won the game 73-0.