The Patriots' 45-point lead at intermission against the Titans (45-0) on Oct. 18, 2009 was the largest halftime lead in NFL history, surpassing the previous mark of 42 when the Packers led the Buccaneers, 49-7, on Oct. 2, 1983.
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The largest NFL score differential was in the 1940 NFL Championship when the Chicago Bears beat the Washington Redskins 73-0. The largest deficit to be overcome and win was 32-0 (Buffalo Bills vs Houston Oilers), which Buffalo won 41-38 in OT.