The NFL record for having the most incompletions in a single game belongs to Eli Manning. He had 35 incompletions and one touchdown during a game versus the Washington Redskins on December 16, 2007.
The Denver Bronco's quarterback who holds the record for the most passing yards in a game was Peyton Manning. He passed the record of Drew Brees
Tim Renowned with 23 vs San Diego
Randall Cuningham vs the Washington Redskins on sept.17 1989
This record is actually a tie between five people, Sid Luckman, Adrian Burk, George Blanda, Y.A. Tittle, and Joe Kapp, all had 7 touchdowns in one game.
Michael Vick of the Atlanta Falcons holds the NFL Quarterback single game rushing record with 173 yards from 10 attempts during a 2002 game vs the Vikings. Nealon Greene of the Edmonton Eskimos holds the CFL Quarterback single game rushing record with 180 yards in 14 carries versus the Saskatchewan Roughriders on July 19, 1999.
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Juice Williams
Brett favre
Tom Brady
The Denver Bronco's quarterback who holds the record for the most passing yards in a game was Peyton Manning. He passed the record of Drew Brees
Former Bears quarterback Sid Luckman holds this record passing for 7 touchdowns on November 14th 1943.
Tim Renowned with 23 vs San Diego
Hall of Fame quarterback Troy Aikman holds the record for the most passing yards in a Thanksgiving day game. He threw for 455 yards versus the Minnesota Vikings 11/26/1998.
Nealon Greene with 180 yards is the CFL record and the NFL record was just set this past weekend
If you are asking which NFL quarterback has thrown the most career TD passes, the answer is Brett Favre. Tom Brady holds the record for most in a season (50), and Joe Kapp holds the record for most in a game (7)
Randall Cuningham vs the Washington Redskins on sept.17 1989
Jeff Handy. Handy holds the Missouri record for passing yards in a game with 480 against Oklahoma State in 1992.