The record for the most passing yards by a college quarterback in his career is held by Timmy Chang. Chang played for University of Hawaii from 2000-2004 and managed to throw for an astonishing 17,072 yards.
John Reaves, who also achieved the all-time passing yardage record, held until Tebow(?)
The Denver Bronco's quarterback who holds the record for the most passing yards in a game was Peyton Manning. He passed the record of Drew Brees
Brett Favre holds the record for most career passing yards, with 71,838.
Case Keenum, quarterback for the Houston Cougars, 2007-11, leads all NCAA divisions with 19,217 passing yards.
Jeff Handy. Handy holds the Missouri record for passing yards in a game with 480 against Oklahoma State in 1992.