Andre Woodson, a quarterback from Kentucky holds the record for most touchdown passes in a season with 40 in 2007
Tom Brady holds the record with 50 touchdown passes in 2007.
Steve Young holds the NFL record of 43. Otto Graham had 44 career rushing TDs but 11 of them came while he played in the AAFC.
Randy Moss holds that record for the New England Patriots. In 2007 he snagged 23 touchdown passes from quarterback Tom Brady.
Steve Largent
Jerry Rice
Bob Hayes (1965-1974) holds the career team record with 71.
Shaun Alexander
Devin Hester (14)
Hersey Walker
This record is actually a tie between five people, Sid Luckman, Adrian Burk, George Blanda, Y.A. Tittle, and Joe Kapp, all had 7 touchdowns in one game.
Brett Favre holds the record for most career touchdown passes with 508. He officially filed his retirement papers with the NFL on January 17, 2011.As of January 03, 2010, Brett Favre has thrown 497 career touchdown passes. He threw for 33 touchdowns in 2009 with only 7 interceptions.He threw for an avg of 7.9 yards per pass, the most in his career. His QB rating of 107.2 was the highest in his career.-------------As of September 30, 2007, Brett Favre has the most NFL touchdown passes with a total of 421.Brett Favre with 508 touchdown passes