Parker Hall, Cleveland vs. Green Bay, Nov. 8, 1942
Frank Sinkwich, Detroit vs. Green Bay, Oct. 24, 1943
Read more: Who_holds_the_record_for_most_interceptions_thrown_in_one_game
Tony Romo in 2007 and Matt Ryan in 2012
The most interceptions Troy Aikman has thrown in one game is 5 vs New York Giants in the 2000 season.
Through Week 7 of the 2010 NFL season, Brady has never thrown 5 interceptions in an NFL game. He has thrown 4 INTs in 5 NFL games, the last time being in the 2006 season against the Colts.
The player was Mitchell Price in the game Tulane vs Tennessee-Chattanooga on Sept 3, 1988 and he had 5.
As of the 2008 season: 1) Brett Favre - 288 2) George Blanda - 277 3) John Hadl - 268 4) Vinny Testaverde - 267 5) Fran Tarkenton - 266
Manning set his personal high with 6 interceptions against the San Diego Chargers on November 11, 2007.
Tom Brady has thrown a total of 103 interceptions in his entire NFL regular season career. In the Playoffs he has thrown a total of 18 bringing the grand total to 121. He has thrown 254 regular season touchdowns and an additional 28 touchdowns in the post season. The most interceptions Brady has thrown an entire season is 14 which he has done three times. In the year the Patriots went 16-0 Brady threw 50 touchdowns and only 8 interceptions. The man is a football GOD!
Rich Gannon threw 5 against the Bucs in Superbowl XXXVII (3 were returned for touchdowns)
The all time leader in interceptions thrown is Brett Favre who, through 9 games of the 2007 season, has thrown 281 career interceptions. Brett Favre has 279 in his career. Answer Brett Farve ended his career with 310. Or so you think
5 interception in one high school football game
Dan Marino!
Six, against the Rams in the 2001 playoffs.