NC State and a 6 seed .
UNC was a number 1 seed in the 2009 NCAA basketball tournament.
Wake Forest was a number 4 seed in the 2009 NCAA Basketball Tournament.
Michigan was a #3 seed when they won the NCAA Men's Basketball Tournament in 1989.
Villanova was an eighth seed in 1985.
Yes.
Kansas
Yes a number 16 seed has beat a number one seed in the NCAA basketball tournament, but it was in the womens' tournament. In 1988, 16th seed Harvard beat 1st seed Stanford in the womens' tourney. (Answer by Mymomisnfat) It also happened in 2018 when the University of Maryland - Baltimore County (16th seed in the South) beat the University of Virginia (1st seed in the South) by a score of 74 - 54.
East Tennessee State was last in the NCAA men's basketball tournament in 2010. They were a #16 seed.
Zags are a college basketball team that played in the NCAA tournament that tabbed the #1 seed.
1 go heels
The Louisville Cardinals are the overall number one seed in the 2009 NCAA tournament and will be playing in the Midwest Region
2 seed Maryland in round of 32