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Start with Barry Sanders 215 in 1988, go from there.

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Q: Who has the most rushing yards in one game against Oklahoma?
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Who broke OJ Simpson's record of 273 rushing yards in a single game?

Walter Payton broke O.J. Simpson's single-game rushing record. Payton gained 275 rushing yards in a 1977 game against the Minnesota Vikings.


What is the NFL record for most combined rushing yards in a game?

Adrian Peterson - 296 Rushing yards on November 4th 2007 against the San Diego Chargers


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In 2003, Jamal Lewis rushed for 295 yards for the Baltimore Ravens against the Cleveland Browns.


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Jamal Lewis of the Baltimore Raavens who rushed for 295 yards in a game against the Cleveland Browns on the September 15, 2003


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Jamal Lewis


Which Denver Broncos running back holds the record for most rushing yards in a regular season game?

Mike Anderson with 251 rushing yards against the New Orleans Saints on December 3, 2000.


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Walter Peyton with 275 yards against the Minnesota Viking on November 20th 1977.


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Tiki Barber with 234 rushing yards against the Washington Redskins on December 30, 2006.


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