Minnesota Vikings RB - Adrian Peterson. He ran for 296 yards against the Chicago Bears in 2007
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Emmitt Smith,with 18,355 rushing yards, currently holds the record for the highest rushing yards in the game.
For a career that is Michael Vick with 7.1 yards per rushing attempt (through 10 games of the 2010 season). Most of the career leaders in this category are quarterbacks. The running back with the highest yards per rushing attempt is Marion Motley at 5.7. For a single season, the record is held by Vick of the 2006 Falcons and running back Beattie Feathers of the 1934 Bears with 8.4 yards per rushing attempt.
The Caucasian with the most rushing yards is John Riggins with 11,352 yards 16th on the all time list. He played from 1971-1985 with the New York Jets and Washington Redskins.
Mike Anderson with 251 rushing yards against the New Orleans Saints on December 3, 2000.
Jim Brown of the Cleveland Browns. Brown played in 118 games and gained 12,312 rushing yards for an average of 104.3 rushing yards per game.
In 2009, the Steelers rushed for a total of 1,793 yards. The team was led by running back Rashard Mendenhall with 1,108 yards.