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Minnesota Vikings RB - Adrian Peterson. He ran for 296 yards against the Chicago Bears in 2007

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15y ago

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Eric Dickerson 248. Divisional game versus the Dallas Cowboys in 1985

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13y ago
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Emmitt Smith,with 18,355 rushing yards, currently holds the record for the highest rushing yards in the game.

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14y ago
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Chris Johnson

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13y ago
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jamal Lewis

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13y ago
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Q: What running back has the highest rushing yards in game?
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