Jamal Lewis of the Baltimore Raavens who rushed for 295 yards in a game against the Cleveland Browns on the September 15, 2003
chris Johnson
Most rushing yards, game: 314, Eddie George(November 11, 1995 vs. Illinois)
O.J. Simpson with 2003 rushing yards for the 1973 Buffalo Bills.
Cory dillon
All-time rushing yards (16,726; now surpassed), Most 100-yard rushing games (77), and Most yards gained rushing in a game (275; now surpassed).
As of 2007, Emmitt Smith holds the record for 18,400 rushing yards. He also holds the record for the most rushing touchdowns with 164. Second place is Ladainian Tomlinson with about 120.
As of the start of the 2007 season, Walter Payton has the second most career rushing yards in NFL history with 16,726. Emmitt Smith is first with 18,355 and Barry Sanders is third with 15,269.
Adrian Peterson - 296 Rushing yards on November 4th 2007 against the San Diego Chargers
Drew Bledsoe has the most negative rushing yards in NFL history.
Marcus depree
From most news Willie Parker of the Pittsburgh Steelers.
Drew Bledsoe has the most negative rushing yards in NFL history.