Jamal Lewis of the Baltimore Raavens who rushed for 295 yards in a game against the Cleveland Browns on the September 15, 2003
chris Johnson
Most rushing yards, game: 314, Eddie George(November 11, 1995 vs. Illinois)
The record for the most rushing yards in a single NFL game is 296 yards, set by Adrian Peterson in 2007.
The player who holds the record for the most NFL rushing yards in a single game is Adrian Peterson, who rushed for 296 yards in a game in 2007.
O.J. Simpson with 2003 rushing yards for the 1973 Buffalo Bills.
Cory dillon
As of 2007, Emmitt Smith holds the record for 18,400 rushing yards. He also holds the record for the most rushing touchdowns with 164. Second place is Ladainian Tomlinson with about 120.
All-time rushing yards (16,726; now surpassed), Most 100-yard rushing games (77), and Most yards gained rushing in a game (275; now surpassed).
As of the start of the 2007 season, Walter Payton has the second most career rushing yards in NFL history with 16,726. Emmitt Smith is first with 18,355 and Barry Sanders is third with 15,269.
Adrian Peterson - 296 Rushing yards on November 4th 2007 against the San Diego Chargers
Drew Bledsoe has the most negative rushing yards in NFL history.
Marcus depree