You can use the ball as defense in the sport of dodgeball.
Baseball
The regulation sport that uses the largest ball is basketball.
Baseball
jai alai (sport)
The sport of bowling.
Beach
The sport of bowling.
Billiards uses a cue ball.
hockey, soccer and all sports involving a ball
Baseball
There is a "double-yellow dot" ball currently used in the sport of squash.
ice hockey