The Los Angeles Lakers beat the Charlotte Bobcats 121 to 53. That is a point differential of 68 points.
39 points with the Boston Celtics winning game 6 and the 2008 NBA finals.
The largest margin of victory in the shot-clock era was 68, when the Cavaliers beat the Heat 148-80 in Cleveland on Dec. 17, 1991
It was the Las Angeles Lakers vs. the record setting (for most losses in a season) Cleveland Cavaliers. The score was 112 - 57; a 55 point differential.
11 runs ... the St. Louis Cardinals defeated the Detroit Tigers 11-0 in Game 7 of the 1934 World Series and the Kansas City Royals defeated the St. Louis Cardinals 11-0 in Game 7 of the 1985 World Series.
I don't know about the minor leagues, but the largest difference in the major leagues is 30-3 (27 runs).
I'm not sure if this one is the biggest scoring differential or not, but in the 1991 Stanley Cup Final game 6 the Pittsburgh Penguins beat the Minnesota North Stars 8-0 to clinch the Stanley Cup. That is the biggest that I recall
The October 7, 1916, American football game between the Georgia Tech Engineers and the Cumberland College Bulldogs (now Cumberland University) was the most-lopsided game in the history of college football. Georgia Tech won, 222-0.
I would say 73 points since the Chicago Bears beat the Washington Redskins 73-0 in an NFL Championship game on December 8th, 1940. Not only did Chicago kill the Redskins but they also set a record for most points in a game set by one team so 73 points has to be the biggest score differential in an NFL game.
1991 Nevada - Weber State 35 point comeback for Nevada to win the game.
The last point of a volleyball game is called the game point. Simple, huh? In the last game of a match, the game point is called the match point.
The Patriots' 45-point lead at intermission against the Titans (45-0) on Oct. 18, 2009 was the largest halftime lead in NFL history, surpassing the previous mark of 42 when the Packers led the Buccaneers, 49-7, on Oct. 2, 1983.
The wild turkey is the largest game bird in North America.