Nope, its never happened
2 seed. 1 has never lost.
In the 1999-2000 season as a 14 seed lost to Ohio State 87-61 in the first round.
Yes, in NCAA tournament history, a number 1 seed has lost in the first round only once. This historic upset occurred in 2012 when the University of Virginia was defeated by 16th-seeded University of Maryland, Baltimore County (UMBC). This game marked a significant moment in college basketball history, as it was the first time a 16 seed triumphed over a 1 seed in the tournament's history.
A 15 seed has never played a 1 seed. Normally, a 16 seed is matched against a 1 seed in the first round, and through the 2009 tournament, the 1 seed has won the first round game 100 times out of 100 tries. A 15 seed has beaten a 2 seed four times, but has never advanced beyond the second round.
At 13-3, they were the 2 seed and got a first round bye. They beat the New England Patriots in the Divisional Round, but lost to the Steelers in the AFC Championship Game
Kansas is a 1 seed, so obviously they are heavily favored. In fact, no #1 seed has ever lost a first round matchup to a 16. So you can almost guarantee that Kansas will win
A 16 seed has never defeated a 1 seed, which is their first opponent of the round of 64
The #3 seed ... they will play the Baltimore Ravens in the first round of the 2008 AFC playoffs.
The #1 seeds are 108-0 against #16 seeds in the NCAA tournament.
In a 10-team single elimination bracket, the top 1 seed receives a bye in the first round, allowing them to automatically advance to the quarterfinals. The remaining 9 teams are then seeded into the first round, typically with the 2 seed facing the 9 seed, the 3 seed facing the 8 seed, and so on, pairing higher seeds against lower seeds. This structure ensures that the stronger teams have an advantageous position in the tournament. The winners of the first round then advance to meet the top seed in the next round.
67 (and 15 losses), which they did in the 2006-2007 season. That was the year they infamously lost to the eighth seed Golden State Warriors in the first round of the playoffs.
The earliest round for a 1 seed to go out in the NCAA basketball tourney is in the first round. It happened in 2018 when the University of Maryland - Baltimore County (16th seed in the South) beat the University of Virginia (1st seed in the South) by a score of 74 - 54.