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The first interleague MLB game was played on June 12, 1997 between the Texas Rangers and the San Francisco Giants. The first interleague home run was hit by Giants right fielder Stan Javier off of Rangers pitcher in the 3rd inning of that game. The Giants won the game 4-3.
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The first home run that was scored by the Arizona Diamondbacks happened on March 31, 1998. It was a sixth inning home run/RBI hit by Travis Lee.
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