Brett Favre has thrown the most touchdown passes in NFL history, with 508.
Montana
Jerry Rice
Brett Favre
Peyton Manning
Walter Payton 8
Joe flacco
tom brady
Drew Brees
u will get no answer mwa ha ha
Tom Brady in 2009 versus the Tennessee Titans, with five.
Brett Favre holds the record for most career touchdown passes with 508. He officially filed his retirement papers with the NFL on January 17, 2011.As of January 03, 2010, Brett Favre has thrown 497 career touchdown passes. He threw for 33 touchdowns in 2009 with only 7 interceptions.He threw for an avg of 7.9 yards per pass, the most in his career. His QB rating of 107.2 was the highest in his career.-------------As of September 30, 2007, Brett Favre has the most NFL touchdown passes with a total of 421.Brett Favre with 508 touchdown passes